Nanometer-Scale Proximal Probe Thermal Desorption Coupled with Laser Mass Spectrometry
نویسندگان
چکیده
The analysis of cultural heritage materials presents a number of obstacles which impose limitations on the range of analytical techniques that can be utilized in their analysis: limited, and extremely small samples, complexity of sample structure, the importance of maintaining spatial integrity and, most importantly, the preciousness of the samples. These limitations present particular challenges for the identification of dyes and pigments within microscopic painting cross sections, in which complex mixtures and thin (often only a few microns) layers of organic material are common.
منابع مشابه
Detection of volatile organic compounds in breath using thermal desorption electrospray ionization-ion mobility-mass spectrometry.
A thermal desorption unit has been interfaced to an electrospray ionization-ion mobility-time-of-flight mass spectrometer. The interface was evaluated using a mixture of six model volatile organic compounds which showed detection limits of <1 ng sample loaded onto a thermal desorption tube packed with Tenax, equivalent to sampled concentrations of 4 microg L(-1). Thermal desorption profiles wer...
متن کاملSubmicron Spatial Resolution in Thermal Desorption Mass Spectrometry via Rapid Heating Functions using Thermal AFM Probes
Atomic Force Microscopy (AFM) combined with Mass Spectrometry (MS) can provide the ability to map and correlate the molecular and physical properties of samples [1, 2] at sub-micron resolutions. Our group has demonstrated such a platform using heated AFM probes [3] for the thermal desorption (TD) of molecules. Current heating techniques typically result in a minimum desorption crater diameter o...
متن کاملOn-probe sample pretreatment for direct analysis of lipids in gram-positive bacterial cells by matrix-assisted laser desorption ionization mass spectrometry.
On-probe sample pretreatment using trifluoroacetic acid as an additional reagent enabled the direct detection of phospholipids in whole bacteria by means of matrix-assisted laser desorption ionization mass spectrometry for not only gram-negative organisms but also gram-positive ones with a thicker peptidoglycan layer.
متن کاملMALDI-TOF MS Coupled with Collision-Induced Dissociation (CID) Measurements of Poly(methyl methacrylate)
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) is one of themost fundamental analysis techniques for proteins, peptides, and synthetic polymers to date. Along with field desorption (FD), fast atom bombardment (FAB), laser desorption coupled with time-of-flight (LD-TOF), secondary ion mass spectrometry coupled with time-of-flight (SIMS-TOF), and electr...
متن کاملInterface for direct and continuous sample-matrix deposition onto a MALDI probe for polymer analysis by thermal field flow fractionation and off-line MALDI-MS.
A simple interface based on an oscillating capillary nebulizer (OCN) is described for direct deposition of eluate from a thermal field-flow fractionation (ThFFF) system onto a matrix-assisted laser desorption/ionization (MALDI) probe. In this study, the polymer-containing eluent from the ThFFF system was mixed on-line with MALDI matrix solution and deposited directly onto a moving MALDI probe. ...
متن کامل